Toxicity of 1,2-dimethlyhydrazine in mice: effect of diet and development of tolerance
Temple, Norman J.
El-Khatib, Shukri M.
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The effect of diet on the lethality of 1, 2-dimethylhydrazine (DMH) injections was investigated using Swiss mice. Mortality was highest when mice were fed a nutrient-dilutealfhigh-fat diet, was intermediate with a nutrientdilutealflow- fat diet and was lowest with laboratory chow. Wheat bran was not protective. Mice developed tolerance to DMH after receiving several injections of progressively increasing dose.